The Aetiology of Deep Venous Thrombosis: A Critical, Historical and Epistemological Survey
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The authors discuss the aetiology of DVT in a historical, philosophical and epistemological context. Finally, they devote a complete chapter to a topic that should be of great interest to researchers and practitioners of critical care medicine and human cryopreservation ; post-mortem blood coagulation. In the following chapters the authors argue that this consensus model is wrongly attributed to Virchow, debunk hypercoagulability and stasis as causes instead of predisposing factors of DVT, and reinterpret the third cause as injury to the venous valve cusp.
In short, the aetiology of DVT the authors propose is that under non-pulsatile flow conditions interruption of the valve cycle will cause blood to be sequestered in the valve sinus, resulting in local hypoxaemia.
Sustained non-pulsatile flow will cause formation of a thrombus on the oxygen-starved parietalis endothelium of the valve cusp leaflets. Practical flow cytometry in haematology diagnosis. Bethesda handbook of clinical hematology. Diagnostic techniques in hematological malignancies.
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