Current Controversies in Bone Marrow Transplantation (Current Clinical Oncology)
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- Three Block War: U.S. Marines in Iraq;
- K Scott Baker, MD, MS.
- Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (vol. 8);
Kurtzberg heads up the pediatric arm of the project. The studies, sponsored by Aastrom Biosciences Inc.
- Bibliographic Information.
- K Scott Baker, MD, MS?
- Related Articles.
- Stem-cell therapy.
In a previously reported study P. Stiff et al.
Conflict of Interests
Conventional bone marrow transplant procedures generally require a liter of bone marrow. There also is evidence, he points out, that the procedure eliminates malignant cells remaining in the bone marrow. Stiff was scheduled to present an updated report of the study at the ASH meeting this month. Hematopoietic stem cell transplants may become the treatment of choice for at least some patients with sickle cell disease SCD and other hemoglobin disorders, including thalassemia. Last year, an international group of researchers published a study showing that 16 of 22 children with SCD were cured by bone marrow transplants from HLA-identical siblings, with stable engraftment of normal blood-forming cells M.
Walters et al. Four of the children rejected the grafts and continue to have SCD , and two died shortly after the transplant.
K Scott Baker, MD, MS
Because of the inherent risks associated with transplantation itself, the patients selected for the trial had already experienced at least one stroke, several episodes of acute chest syndrome, or painful crises-three of the most common and disabling symptoms of SCD. Sullivan, a professor of medicine at the University of Washington and member of the Fred Hutchinson Cancer Research Center in Seattle, who was principal investigator of the study.
Since that paper was published, the group has added another 12 children to the study. For most of the children, the greatest barrier to the study was having an HLA-identical sibling, not the cost associated with the transplant. Fewer than 10 percent of the patients were turned down by their insurance carriers for the trial.
Indeed, Sullivan explains, state and insurance agencies were often supportive of the National Institutes of Health-approved study. Aastrom Biosciences Inc. Box Ann Arbor, Mich. Box Milwaukee, Wis. These observations led researchers to suggest a graft-vs.
Current Controversies in Bone Marrow Transplantation
The most striking evidence in support of the GVL effect is that about 70 percent of patients with chronic myelogenous leukemia CML who relapse can be put into remission with only an infusion of donor lymphocytes. Anderson's Richard Champlin uses donor lymphocyte infusion for patients who can't tolerate very-high-dose chemotherapy.
Richard E. Champlin, chief of the section of bone marrow transplantation at the University of Texas M.
Advances In Bone Marrow Transplantation Improve Safety | The Scientist Magazine®
Anderson Cancer Center in Houston, has begun using donor lymphocyte infusion as a front-line therapy for patients with hematologic malignancies R. Champlin et al. Then we give the transplant and allow it to mediate its immune anti-tumor effects. Champlin has used this method to treat about 50 patients in a series of trials, and while he says that longer follow-up will be needed to assess the long-term effectiveness of the approach, about 40 percent of the patients in the largest trial are alive and free of disease.
One novel approach now undergoing evaluation in clinical trials uses suicide gene therapy to eliminate the GVHD-causing T cells C. Bordignon et al. The donor lymphocytes are transduced with the herpes simplex virus thymidine kinase TK gene, rendering them sensitive to ganciclovir treatment. Any ensuing GVHD can be stopped by ganciclovir treatment.
Government funding for clinical trials remains inadequate, many researchers stress. AB - Loss of appetite and weight predict a poor prognosis for cancer patients.
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